Dr. Oti-Boateng is currently the Director of the Division of Science Policy and Capacity Building in the Natural Sciences Sector at UNESCO. In the past, she has been responsible for projects and programmes relating to science policy and basic sciences  at the multisectoral regional office in Harare (Zimbabwe). She was regional thematic adviser for Africa for the formulation of policies and capacity building in science, technology and innovation. She also served as focal point for the African Ministerial Conference on Science and Technology and was the Head of the Sciences Sector for the Southern African Development Community. She had additional responsibilities in the area of water sciences, ecology and intersectionality.

Dr. Oti-Boateng holds a PhD in Food Science and Technology obtained from Adelaide University in Australia and an MSc, with a specialization in Biochemistry, obtained from the Kwame Nkrumah University of Science and Technology in Kumasi (Ghana).  Dr. Oti-Boateng began her career in 1985 as a researcher at the Technology Consultancy Centre at the College of Engineering at KNUST. In 1989 she was appointed Consultant and Trainer at the South Australian Department for Training and Employment in Adelaide (Australia) and from 2005 to 2010, she served as Director of the Research Centre at the Kwame Nkrumah University of Science and Technology, working in collaboration with national and international strategic partners. In 2011, Dr. Oti-Boateng joined the UNESCO Office in Nairobi, Kenya as a Senior Programme Specialist . In this capacity, she was responsible for developing, coordinating, implementing and evaluating projects and programmes of activities relating to the basic sciences and science policy for sustainable development in Africa. In 2015, Dr. Oti-Boateng was transferred to the multisectoral regional office in Harare (Zimbabwe) and since 2018 she holds the position of Director of Division at UNESCO Headquarters.